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Axitinib-induced acute pancreatitis: a case report
Julien Péron1, Safia Khenifer, Valérie Potier
1Departments of aOncology and Internal Medicine bDigestive Diseases cRadiology, Desgenettes Hospital, University of Lyon, Lyon, France.
Anti-Cancer Drugs
|January 9, 2014
Summary
Axitinib, a targeted therapy for advanced renal cell carcinoma, may cause acute pancreatitis. This first report suggests a link, highlighting the need for vigilance in patients receiving this cancer treatment.
Area of Science:
- Oncology
- Pharmacology
Background:
- Axitinib is a targeted therapy for advanced renal cell carcinoma.
- Previous tyrosine kinase inhibitors (TKIs) like sorafenib and sunitinib have been linked to acute pancreatitis.
Observation:
- A 29-year-old woman developed acute pancreatitis during axitinib treatment.
- The patient had no other risk factors for pancreatitis.
- Pancreatitis resolved after discontinuing axitinib.
Findings:
- This case suggests a potential association between axitinib and acute pancreatitis.
- Axitinib may be an etiological factor in drug-induced pancreatitis.
Implications:
- Acute pancreatitis should be considered a potential adverse event of axitinib therapy.
- Clinicians should monitor patients on axitinib for signs of pancreatitis.
- Further investigation into axitinib-induced pancreatitis is warranted.
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