Related Experiment Video
Updated: May 4, 2026
06:31
Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
Published on: October 6, 2023
3.8K
Pseudorheumatoid disability man with chronic tophaceous gout: a case report
Rodica Trăistaru1, Viorela Enăchescu, Diana Kamal
1Department of Physical Medicine and Rehabilitation, University of Medicine and Pharmacy of Craiova, Romania; rodicatraistru@hotmail.com.
Summary
Gout, characterized by monosodium urate (MSU) crystal buildup, causes inflammatory arthritis. This case highlights the importance of comprehensive assessment for severe chronic tophaceous gout, especially in the hands.
Area of Science:
- Rheumatology
- Biochemistry
- Pathology
Background:
- Gout is an inflammatory arthropathy caused by monosodium urate (MSU) crystal deposition in joints.
- It is the most common inflammatory arthritis in men over 40, linked to elevated serum urate (SU) levels.
- Chronic MSU crystal accumulation leads to tophi and synovitis, causing functional disability.
Observation:
- A case study of a 48-year-old male with severe chronic tophaceous gout is presented.
- The patient exhibited chronic hand arthritis and a history of urolithiasis.
- Soft tissue lesions, particularly in the hands, were a key feature.
Findings:
- Severe chronic tophaceous gout can manifest with significant hand involvement.
- Urolithiasis may coexist with severe gouty arthritis.
- Complex assessment including clinical, functional, imaging, and histological data is crucial.
Implications:
- Comprehensive diagnostic approaches are vital for managing complex gout cases.
- Early and accurate diagnosis of soft tissue lesions in gout can prevent functional decline.
- Understanding the multifaceted nature of gout aids in developing effective treatment strategies.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
12.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.6K
01:21Rheumatic Heart Disease III: Medical Management
544
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
544
01:23Rheumatic Heart Disease I: Introduction
1.0K
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
1.0K
01:26Nephrotic Syndrome II : Assessment and Medical Management
409
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
409
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
1.3K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.3K
01:24Nephrotic Syndrome I : Introduction
1.2K
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
1.2K