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Related Experiment Video

Updated: May 4, 2026

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
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Orbital exenteration - a salvage procedure?

A Frunză1, D Slăvescu, D Zamfirescu

  • 1Department of Plastic Surgery and Reconstructive Microsurgery, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; dragoszamfirescu@gmail.com.

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|January 9, 2014
PubMed
Summary
This summary is machine-generated.

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Orbital exenteration surgery for aggressive midface tumors offers good disease control and quality of life. Reconstruction balances healing, defect repair, and early detection of recurrent cancer.

Area of Science:

  • Oncology
  • Ophthalmology
  • Plastic Surgery

Background:

  • Orbital exenteration is a complex surgical procedure primarily indicated for orbital malignancies.
  • Reconstructive strategies aim for rapid healing, disease surveillance, and functional restoration.
  • Tailored surgical approaches are crucial for managing 3D orbital defects and ensuring patient quality of life.

Observation:

  • A series of three patients with aggressive midface tumors underwent orbital exenteration for tumor clearance.
  • The study reviewed cases admitted over a four-year period.
  • Surgical outcomes were generally favorable, with one exception.

Findings:

  • Orbital exenteration successfully achieved tumor clearance in the presented cases.
  • One patient with squamous cell carcinoma and perineural invasion experienced a disease relapse at three years.

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  • Reconstruction facilitated stable healing and functional recovery post-exenteration.

    • Implications:

    • Orbital exenteration is a viable option for managing extensive midface malignancies.
    • Careful patient selection and tailored reconstruction are key to optimizing outcomes.
    • Long-term surveillance is essential, particularly in cases with risk factors like perineural invasion.