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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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[Epigenetics in inflammatory systemic diseases].

C Ospelt1, S Gay

  • 1Zentrum für Experimentelle Rheumatologie, Klinik für Rheumatologie, UniversitätsSpital Zürich, Gloriastr. 23, 8091, Zürich, Schweiz, caroline.ospelt@usz.ch.

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Summary
This summary is machine-generated.

Epigenetic modifications, influenced by environmental factors, regulate gene expression and cell phenotype. These changes are linked to disease progression and may offer future therapeutic targets and biomarkers.

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Area of Science:

  • Molecular Biology
  • Genetics
  • Epigenetics

Context:

  • Focus shifting from genetic code to epigenetic code analysis.
  • Epigenetic mechanisms control gene transcription and cellular phenotype.
  • Environmental influences dynamically alter the epigenetic code for adaptation.

Purpose:

  • Investigate the role of epigenetic changes in long-term environmental effects on disease.
  • Explore the correlation between epigenetic modifications and disease severity/progression.

Summary:

  • Epigenetic alterations are implicated as the molecular basis for environmentally induced diseases.
  • Significant correlations found between epigenetic changes and the progression of tumors and chronic inflammatory diseases.

Impact:

  • Potential for epigenetic modifications to serve as future biomarkers.
  • Prognostic factors for disease severity and progression.
  • Novel therapeutic targets for disease intervention.