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Olfactory receptor cell function is affected by trigeminal nerve activity.

J F Bouvet, J C Delaleu, A Holley

    Neuroscience Letters
    |June 15, 1987
    PubMed
    Summary
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    Electrical stimulation of the frog's trigeminal nerve (NV-ob) affects olfactory receptor cells. This suggests the trigeminal system modulates olfactory function, possibly via substance P (SP) release.

    Area of Science:

    • Neuroscience
    • Olfactory System Research
    • Sensory Physiology

    Background:

    • The olfactory system's function is crucial for animal behavior.
    • The trigeminal nerve (NV-ob) innervates the nasal cavity and plays a role in sensory perception.
    • Interactions between the olfactory and trigeminal systems are not fully understood.

    Purpose of the Study:

    • To investigate the influence of the trigeminal nerve on olfactory mucosa activity.
    • To explore the role of substance P (SP) in trigeminal-olfactory interactions.
    • To determine if the trigeminal system modulates olfactory receptor cell function.

    Main Methods:

    • Antidromic electrical stimulation of the frog's ophthalmic branch of the trigeminal nerve (NV-ob).
    • Recording of slow electrical potentials in the olfactory mucosa.

    Related Experiment Videos

  • Application of Substance P (SP) to the olfactory mucosa.
  • Monitoring of olfactory receptor cell activity and odorant response modulation.

    • Main Results:

    • Electrical stimulation of NV-ob evoked slow potentials in the olfactory mucosa.
    • NV-ob stimulation modified olfactory receptor cell activity.
    • Substance P (SP) application mimicked the electrical responses induced by NV-ob stimulation.
    • Odorant-evoked responses in the olfactory system were modulated by NV-ob stimulation.

    Conclusions:

    • The trigeminal system, via NV-ob, can modulate olfactory system activity at the receptor cell level.
    • Substance P (SP) is likely involved in the trigeminal modulation of olfactory function.
    • A local axon reflex in the trigeminal nerve may lead to SP release, influencing olfactory perception.