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Yersinia pestis: mechanisms of entry into and resistance to the host cell

Yuehua Ke1, Zeliang Chen2, Ruifu Yang3

  • 1Institute of Disease Control and Prevention, Academy of Military Medical Sciences Beijing, China ; Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences Beijing, China.

Frontiers in Cellular and Infection Microbiology
|January 9, 2014
PubMed

Insights

Yersinia bacteria invade host cells and then evade immune cells. This study explores the unclear mechanisms Yersinia uses to switch between invasion and immune evasion strategies.

Area of Science:

  • Microbiology
  • Bacterial Pathogenesis
  • Cellular Biology

Background:

  • Yersinia are facultative intracellular bacteria known for invading host cells.
  • Following invasion, Yersinia can counteract host cell phagocytosis.
  • The regulatory mechanisms controlling these distinct Yersinia functions are not well understood.

Purpose of the Study:

  • To discuss factors in Yersinia that appear to function reversely.
  • To hypothesize how Yersinia switches between invasion and antiphagocytic statuses.

Main Methods:

  • This study is a discussion and hypothesis generation based on existing literature.
  • No new experimental data was generated.

Main Results:

  • Identified bacterial factors that may play dual roles in invasion and immune evasion.
  • Proposed potential regulatory pathways for switching between distinct functional states.

Conclusions:

  • Understanding Yersinia's regulatory mechanisms is crucial for deciphering its pathogenesis.
  • Further research is needed to elucidate the precise molecular switches governing Yersinia's host-interaction strategies.
Keywords:
T3SSanti-phagocytosisintracellular survivalinvasion

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