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Related Concept Videos

Determination01:51

Determination

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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The Mouse Hindbrain As a Model for Studying Embryonic Neurogenesis
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Temporal fate specification and neural progenitor competence during development.

Minoree Kohwi, Chris Q Doe

    Nature Reviews. Neuroscience
    |January 9, 2014
    PubMed
    Summary

    Neural progenitors in the central nervous system (CNS) develop diverse cells by regulating gene expression and chromatin. Understanding this process aids in generating cells for brain repair.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Genetics

    Background:

    • The central nervous system (CNS) comprises diverse neurons and glia originating from a limited progenitor pool.
    • Neural progenitor development involves sequential transcriptional changes to specify distinct cell fates.
    • Both intrinsic and extrinsic factors guide progenitor behavior to form functional neural circuits.

    Purpose of the Study:

    • To explore the mechanisms of temporal-identity specification in neural progenitors.
    • To understand progenitor competence in generating specific cell types.
    • To investigate how chromatin architecture changes influence cell fate decisions.

    Main Methods:

    • Analysis of transcriptional changes during neural development.
    • Investigation of cell-intrinsic and cell-extrinsic cues.

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  • Examination of global chromatin architecture modifications.
  • Studies on progenitor competence and temporal identity.

    • Main Results:

    • Neural progenitors undergo dynamic transcriptional changes to specify cell fates.
    • Progenitor development is guided by intrinsic and extrinsic signals for circuit formation.
    • Changes in chromatin architecture restrict the timing of cell type generation.

    Conclusions:

    • Temporal identity and progenitor competence are crucial for CNS development.
    • Understanding these processes can inform strategies for neural repair.
    • Targeting chromatin and temporal regulation may enhance cell generation for brain repair.