Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

4.3K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.3K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

2.0K
2.0K
Epigenetic Regulation01:37

Epigenetic Regulation

3.5K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.5K
Epigenetic Regulation01:46

Epigenetic Regulation

28.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
28.7K
Epigenetic Regulation01:46

Epigenetic Regulation

24.1K
24.1K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

3.8K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Catalytic synthesis of sulfated polysaccharides I: Characterization of chemical structure.

International journal of biological macromolecules·2014
Same author

MiR-335 inhibits migration of breast cancer cells through targeting oncoprotein c-Met.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine·2014
Same author

Dynamic ambulance reallocation for the reduction of ambulance response times using system status management.

The American journal of emergency medicine·2014
Same author

Sophorolipid production from biomass hydrolysates.

Applied biochemistry and biotechnology·2014
Same author

[Research on progress and prospect of kinase S6K1].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi·2014
Same author

Amplified fluorescent aptasensor through catalytic recycling for highly sensitive detection of ochratoxin A.

Biosensors & bioelectronics·2014
Same journal

Construction and implementation of an ICF-based integrated teaching model for genetic disease severity assessment.

Yi chuan = Hereditas·2026
Same journal

Identification and prenatal genetic testing of pathogenic variants in a case of myoclonus-dystonia syndrome.

Yi chuan = Hereditas·2026
Same journal

A novel strategy to enhance precise targeting of the RNA base editor mxABE.

Yi chuan = Hereditas·2026
Same journal

Functional study of the soybean rapid alkalinization factor <i>GmRALF34s</i> in response to saline-alkali stress.

Yi chuan = Hereditas·2026
Same journal

Role of <i>broad</i> in intestinal stem cells of adult <i>Drosophila</i>.

Yi chuan = Hereditas·2026
Same journal

The p53 R267W mutation intervenes p21-mediated cell cycle arrest and promotes proliferation and migration of lung cancer cells.

Yi chuan = Hereditas·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

6.0K

[Epigenetics in cancer stem cells].

Li-Fan Xu1, Ji Zhang2, Zhi-Qiang Tian2

  • 1Department of Immunology, The Third Military Medical University, Chongqing 400038, China. xlftofu@sina.com

Yi Chuan = Hereditas
|January 10, 2014
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) drive tumor growth and resistance. Epigenetic mechanisms, including DNA methylation and histone modifications, are crucial for regulating these cancer stem cell properties.

More Related Videos

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.2K
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

8.2K

Related Experiment Videos

Last Updated: May 4, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

6.0K
Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.2K
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

8.2K

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Epigenetics

Context:

  • Cancer stem cells (CSCs) are a critical component of tumor biology.
  • CSCs are implicated in tumor initiation, metastasis, relapse, and therapeutic resistance.
  • Understanding CSC regulation is vital for developing effective cancer treatments.

Purpose:

  • This review focuses on the key epigenetic mechanisms regulating cancer stem cell properties.
  • To elucidate the role of epigenetics in the generation and maintenance of CSCs.

Summary:

  • Cancer stem cells (CSCs) share self-renewal and differentiation capacities with normal stem cells.
  • Epigenetic mechanisms, such as DNA methylation, histone modifications, chromatin remodeling, and microRNAs (miRNAs), are pivotal in regulating CSC features.
  • This review highlights the critical epigenetic regulators that define CSC properties.

Impact:

  • Provides insights into the epigenetic basis of cancer stem cell function.
  • Highlights potential therapeutic targets for cancer treatment by modulating epigenetic pathways.
  • Advances the understanding of tumor evolution and resistance mechanisms.