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The J-curve relationship between diastolic pressure and coronary collateral circulation in patients with single

Wang Shu1, Wang Jin Da1, Liu Chang Fu1

  • 1The Cardiovascular Medical Department of the General Hospital of Chinese People of Liberation Army, Fu Xin Road Number 28, Beijing 100853, China.

Atherosclerosis
|January 10, 2014
PubMed

Insights

Diastolic blood pressure (DBP) exhibits a J-curve relationship with poorly-developed coronary collateral circulation (CCC). This finding may explain the link between DBP and cardiovascular risk.

Area of Science:

  • Cardiovascular Science
  • Medical Research

Background:

  • Previous research indicated a positive association between high diastolic blood pressure (DBP) and well-developed coronary collateral circulation (CCC).
  • Further investigation was needed to precisely define the relationship between DBP and CCC.

Purpose of the Study:

  • To elucidate the precise relationship between diastolic blood pressure (DBP) and the development of coronary collateral circulation (CCC).

Main Methods:

  • A study involving 671 patients with single chronic total coronary artery occlusion was conducted.
  • Diastolic blood pressure (DBP) levels were categorized into six groups.
  • Coronary collateral circulation (CCC) was assessed using the Rentrop classification.

Main Results:

  • A J-curve relationship was observed between diastolic blood pressure (DBP) levels and the incidence of poorly-developed coronary collateral circulation (CCC).
  • This indicates that both low and high DBP levels are associated with poorer collateral development.

Conclusions:

  • The relationship between DBP and CCC mirrors the J-curve observed between DBP and cardiovascular risk.
  • DBP's influence on CCC development might be a key pathophysiological mechanism underlying the DBP-cardiovascular risk J-curve phenomenon.
Abstract

Keywords:
Coronary collateral circulationDiastolic blood pressureJ-curve phenomenon

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