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Serum calcium and phosphate concentrations and intracranial atherosclerosis

K Kang1

  • 1Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea; Department of Neurology, Gyeongsang National University Hospital, Jinju, Republic of Korea.

Atherosclerosis
|January 10, 2014
PubMed

Insights

Higher corrected serum calcium levels are linked to an increased risk of intracranial atherosclerosis in stroke-free individuals. This finding highlights the importance of monitoring calcium levels for brain health.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Serum calcium and phosphate are known risk factors for stroke and extracranial carotid atherosclerosis.
  • The association between serum calcium, phosphate, and intracranial atherosclerosis remains less understood.

Purpose of the Study:

  • To investigate the relationship between serum calcium and phosphate concentrations and the presence of intracranial atherosclerosis.
  • To evaluate these associations in a stroke-free Korean population.

Main Methods:

  • Retrospective analysis of 361 stroke-free individuals.
  • Measurement of serum calcium, phosphate, and albumin levels.
  • Brain magnetic resonance angiography to assess intracranial arteries (basilar, middle cerebral, internal carotid, vertebral).
  • Serum calcium levels were corrected for albumin concentration.

Main Results:

  • 21% of subjects had intracranial atherosclerosis.
  • Higher quartiles of corrected serum calcium were significantly associated with increased odds of intracranial atherosclerosis (ORs ranging from 3.11 to 3.77).
  • Serum phosphate and uncorrected serum calcium concentrations showed no significant association with intracranial atherosclerosis.

Conclusions:

  • Corrected serum calcium concentration is a significant positive predictor of intracranial atherosclerosis.
  • These findings suggest that monitoring corrected serum calcium may be important for assessing the risk of intracranial atherosclerosis.
Abstract

Keywords:
Brain magnetic resonance angiographyCalciumIntracranial atherosclerosisPhosphate

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