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Association between cardiotrophin 1 levels and central blood pressure in untreated patients with essential

Eugenia Gkaliagkousi1, Eleni Gavriilaki, Barbara Nikolaidou

  • 12nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

American Journal of Hypertension
|January 10, 2014
PubMed

Insights

Cardiotrophin 1 (CT-1) is elevated in untreated essential hypertension (EH) patients and correlates with higher blood pressure and arterial stiffness. This suggests CT-1 may play a role in cardiovascular damage in EH.

Area of Science:

  • Cardiovascular Research
  • Hypertension Pathophysiology
  • Cytokine Signaling

Background:

  • Cardiotrophin 1 (CT-1), an IL-6-related cytokine, is linked to cardiac hypertrophy and vascular damage.
  • Essential hypertension (EH) is a condition associated with cardiovascular risks.

Purpose of the Study:

  • To quantify CT-1 levels in untreated grade I EH patients versus normotensive (NT) individuals.
  • To explore the relationship between CT-1 levels and arterial stiffness indices in EH.

Main Methods:

  • Enrolled 45 untreated grade I EH patients and 25 NT subjects.
  • Measured CT-1 levels using ELISA.
  • Assessed arterial stiffness via applanation tonometry.

Main Results:

  • CT-1 levels were significantly higher in EH patients (P < 0.001).
  • CT-1 positively correlated with office, ambulatory, and central blood pressure.
  • CT-1 levels showed a significant correlation with pulse wave velocity (P = 0.02).
  • Central systolic and diastolic BP were the sole significant predictors of CT-1 in multivariable analysis.

Conclusions:

  • This study is the first to link CT-1 levels with ambulatory/central BP and pulse wave velocity in EH.
  • CT-1's role in the cardiovascular system of EH patients warrants further investigation.
Abstract

Keywords:
arterial stiffnessblood pressurecardiotrophin-1central blood pressureessential hypertensionhypertension.

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