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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Alterations in Muscle Tone lll01:11

Alterations in Muscle Tone lll

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Rigidity and myotonia are distinct abnormalities of muscle tone that affect resistance and relaxation during movement. Although both involve altered muscle contraction, they arise from different neurological and muscular mechanisms.CharacteristicsRigidity is characterized by uniform resistance to passive movement across the entire range, independent of speed, affecting flexors and extensors equally. It may appear as lead-pipe rigidity (smooth, constant resistance) or cogwheel rigidity...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Updated: May 4, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

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Muscle dysfunction in cancer patients.

J F Christensen1, L W Jones, J L Andersen

  • 1The University Hospitals Centre for Health Care Research (UCSF).

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|January 10, 2014
PubMed
Summary
This summary is machine-generated.

Cancer patients frequently experience muscle dysfunction, impacting mortality and quality of life. Exercise interventions show promise in mitigating these effects, with future trials needing optimized timing for early-stage and advanced cancer patients.

Keywords:
cancerexercisemuscle massmuscle strengthskeletal muscle

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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Area of Science:

  • Oncology
  • Exercise Science
  • Muscle Physiology

Background:

  • Muscle dysfunction is common in cancer patients, irrespective of tumor stage or nutritional status.
  • This review examines the extent, causes, and clinical significance of muscle dysfunction in cancer.
  • The role of exercise training in preventing or alleviating cancer-related muscle dysfunction is discussed.

Purpose of the Study:

  • To review current evidence on muscle dysfunction in cancer patients.
  • To explore the causes and clinical implications of cancer-related muscle dysfunction.
  • To discuss the efficacy of exercise interventions in managing muscle dysfunction.

Main Methods:

  • A comprehensive literature search was conducted using PubMed and EMBASE databases.
  • 194 studies investigating muscular outcomes in cancer patients were identified and analyzed.

Main Results:

  • Muscle dysfunction occurs across all cancer stages and stems from complex tumor-, therapy-, and lifestyle-related factors.
  • Muscle dysfunction is linked to critical outcomes like mortality, treatment complications, and reduced quality of life (QoL).
  • Exercise training is a powerful intervention for modulating skeletal muscle function in cancer patients.

Conclusions:

  • Muscle dysfunction is clearly associated with significant clinical outcomes in cancer.
  • A gap exists between the timing of effective exercise interventions and patient populations where muscle function is prognostically important.
  • Future exercise trials should target early-stage patients to assess clinical outcomes or advanced-stage patients to reverse dysfunction, potentially improving progression-free survival and reducing toxicity.