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Negative associations between arterial stiffness parameter evaluated by cardio-ankle vascular index and serum

Satoki Homma1, Kiyoe Kato2, Junichi Hayashi3

  • 1Department of General Medicine, School of Medicine, Kyorin University, Tokyo, Japan satoki.homma@nifty.com.

Angiology
|January 10, 2014
PubMed

Insights

The cardio-ankle vascular index (CAVI), a measure of arterial stiffness, showed a negative association with low-density lipoprotein cholesterol (LDL-C) in patients without significant risk factors.

Area of Science:

  • Cardiovascular Research
  • Biomarkers
  • Arterial Stiffness

Background:

  • The cardio-ankle vascular index (CAVI) reflects aortic and lower limb arterial stiffness.
  • Previous studies report inconsistent associations between CAVI and low-density lipoprotein cholesterol (LDL-C).

Purpose of the Study:

  • To investigate the relationship between CAVI and serum lipid levels, specifically LDL-C and non-high-density lipoprotein cholesterol (non-HDL-C).
  • To examine if this association is modified by the presence of cardiovascular risk factors or the extent of atherosclerosis.

Main Methods:

  • Cross-sectional study of 1878 patients undergoing health checkups.
  • Age-adjusted correlation and multiple regression analyses were performed.
  • Subgroup analyses were conducted based on risk factor status and maximum carotid intima-media thickness (maxIMT).

Main Results:

  • A significant negative correlation was observed between CAVI and LDL-C/non-HDL-C in the overall cohort.
  • This negative correlation was only present in subgroups with lower cardiovascular risk (e.g., non-diabetics, maxIMT <1.0 mm).
  • No significant correlation was found in higher-risk patient groups.

Conclusions:

  • The association between arterial stiffness (CAVI) and LDL-C is dependent on the presence of cardiovascular risk factors.
  • In individuals with low atherosclerotic burden, higher LDL-C may be associated with lower arterial stiffness.
  • Further research is needed to elucidate the complex interplay between lipids, atherosclerosis, and arterial stiffness.

Keywords:
arterial stiffnessatherosclerosiscardio-ankle vascular indexlow-density lipoprotein cholesterolrisk factors

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