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New daily persistent headache and potential new therapeutic agents
Shivang G Joshi1, Paul G Mathew, Herbert G Markley
1Department of Neurology, New England Regional Headache Center, University of Massachusetts Medical School, 85 Prescott Street Suite 101, Worcester, MA, 01605, USA, sjoshi@nerhc.org.
Current Neurology and Neuroscience Reports
|January 10, 2014
Summary
New daily persistent headache (NDPH) is a challenging chronic headache. Its exact cause is unknown, but tumor necrosis factor may be involved, requiring further investigation for effective treatments.
Area of Science:
- Neurology
- Headache Medicine
Background:
- New daily persistent headache (NDPH) is a distinct subtype of chronic daily headache.
- It is characterized by a unique temporal profile, with patients recalling the exact onset day.
- NDPH is often refractory to treatment, highlighting the need for better understanding.
Purpose of the Study:
- To discuss the clinical features of NDPH.
- To explore the differential diagnosis for NDPH.
- To review potential new therapeutic agents for NDPH.
Main Methods:
- Literature review of recent publications on NDPH.
- Analysis of clinical features and heterogeneity in presentation.
- Exploration of potential pathophysiological mechanisms, including the role of tumor necrosis factor.
Main Results:
- NDPH presents unique diagnostic challenges.
- Treatment outcomes with current medications are mixed.
- Tumor necrosis factor is a potential factor in NDPH pathophysiology.
Conclusions:
- NDPH requires further research into its pathophysiology.
- Identifying subtypes and understanding heterogeneity is crucial.
- New therapeutic strategies are needed for refractory NDPH cases.
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