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[Transplant cross-over, an attractive option]

Emanuela Maddalena

    Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
    |January 10, 2014
    PubMed

    Insights

    Kidney exchange programs offer solutions for patients with end-stage renal disease facing donor incompatibility. These programs facilitate transplants through paired donations and complex chains, overcoming blood type and antibody barriers.

    Area of Science:

    • Nephrology
    • Transplantation immunology
    • Medical ethics

    Context:

    • Living donor kidney transplantation is a preferred option for end-stage renal disease.
    • 10-20% of potential living donor-recipient pairs face incompatibility due to blood type or donor-specific antibodies.
    • Kidney exchange programs (KEP) and desensitization protocols are strategies to overcome these barriers.

    Purpose:

    • To describe various types of kidney exchange programs, including two-way Kidney Paired Donation and complex chains (NEAD chains).
    • To discuss ethical, cultural, and social arguments surrounding kidney exchanges, particularly in Italy.

    Summary:

    • Kidney exchange programs facilitate incompatible living donor transplants.
    • These programs range from simple two-way exchanges to complex chains initiated by altruistic donations.
    • The discussion includes ethical and socio-cultural considerations of implementing kidney exchanges.

    Impact:

    • KEP expands the donor pool for patients with end-stage renal disease.
    • Facilitates transplantation for previously incompatible pairs.
    • Informs ethical and policy debates regarding organ transplantation.

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