Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

269
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
269
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

209
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
209
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

359
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
359
Cross-reactivity00:42

Cross-reactivity

28.7K
Overview
28.7K
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

208
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
208
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.4K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimizing influenza vaccine allocation: A predictive analytics approach for informed public health planning.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2024
Same author

Measuring What Counts to Advance Indigenous Self-Determination: A Case Study of the Nisg̱a'a Lisims Government's Quality of Life Framework and Survey.

International journal of community well-being·2021
Same author

Hidradenitis Suppurativa in the Military.

Cutis·2020
Same author

Analysis of surgical options for patients with bilateral carpal tunnel syndrome.

Journal of orthopaedics·2020
Same author

Emergency Nurses' Perception of Geriatric Readiness in the ED Setting: A Mixed-Methods Study.

Journal of emergency nursing·2019
Same author

An Approach to the Older Patient in the Emergency Department.

Clinics in geriatric medicine·2018

Related Experiment Video

Updated: May 4, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

14.5K

Erythema multiforme following smallpox vaccination.

Erin B Storie1, Adam Perry2

  • 1Marine Attack Squadron 311, PO Box 99250, MCAS Yuma, AZ 85369-9250.

Military Medicine
|January 10, 2014
PubMed
Summary
This summary is machine-generated.

Erythema multiforme (EM) is a skin reaction that can occur after vaccinations. This case study highlights a service member who developed EM 14 days post-smallpox vaccination.

More Related Videos

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

8.2K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

13.8K

Related Experiment Videos

Last Updated: May 4, 2026

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

14.5K
Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response
06:31

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

8.2K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

13.8K

Area of Science:

  • Dermatology
  • Vaccinology
  • Public Health

Background:

  • Erythema multiforme (EM) is an acute, self-limiting skin condition with diverse triggers, including infections, medications, and vaccinations.
  • Smallpox vaccination programs, particularly for military personnel, necessitate awareness of potential adverse reactions.
  • Accurate diagnosis of EM is crucial due to its variable presentation.

Observation:

  • A 19-year-old active duty male presented with symptoms of Erythema multiforme.
  • The onset of EM occurred 14 days following administration of the smallpox vaccine.

Findings:

  • The case illustrates a temporal association between smallpox vaccination and the development of Erythema multiforme.
  • This adverse reaction, though infrequent, warrants consideration in post-vaccination surveillance.

Implications:

  • Military healthcare providers should be vigilant for Erythema multiforme as a potential adverse reaction to smallpox vaccination.
  • Increased awareness can lead to timely diagnosis and management, ensuring service member readiness.
  • Understanding vaccination side effects is vital for maintaining confidence in immunization programs.