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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Detection of microRNA Expression in Peritoneal Membrane of Rats Using Quantitative Real-time PCR
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Detection of microRNA Expression in Peritoneal Membrane of Rats Using Quantitative Real-time PCR

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[Micro RNA-155 expression in hemodialysis PBMC].

Paolo Albrizio, M Gnecchi, E Cervio

    Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
    |January 10, 2014
    PubMed
    Summary
    This summary is machine-generated.

    MicroRNA-155 (miR-155) is significantly upregulated in peripheral blood mononuclear cells (PBMC) of hemodialysis patients compared to healthy individuals. This upregulation is also observed after PHA stimulation, but not significantly altered by hemodialysis sessions.

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    Area of Science:

    • Molecular Biology
    • Genetics
    • Biochemistry

    Context:

    • MicroRNAs (miRNAs) are crucial post-transcriptional regulators of gene expression involved in various pathophysiological processes.
    • Chronic kidney disease patients undergoing hemodialysis exhibit altered cellular functions and inflammatory states.

    Purpose:

    • To investigate the expression levels of miR-155 in peripheral blood mononuclear cells (PBMC) from chronic hemodialysis (HD) patients.
    • To compare miR-155 expression in HD patients' PBMC before and after hemodialysis sessions.
    • To assess the effect of phytohemagglutinin (PHA) stimulation on miR-155 expression in HD patients' PBMC.

    Summary:

    • Real-Time PCR analysis revealed significantly higher miR-155 relative quantity (RQ) in pre-dialysis PBMC of HD patients compared to healthy controls (3.77-fold increase, P=0.003).
    • PHA stimulation further increased miR-155 RQ in HD patients' PBMC (1.79-fold increase, P=0.019) compared to non-stimulated PBMC.
    • No significant difference in miR-155 expression was observed in HD patients' PBMC before and after hemodialysis sessions.

    Impact:

    • These findings indicate a significant upregulation of miR-155 in HD patients' PBMC, suggesting its potential role in the pathophysiology of chronic kidney disease.
    • The observed miR-155 upregulation, particularly after PHA stimulation, may point towards an altered immune response in HD patients.
    • Further research is warranted to elucidate the functional consequences of miR-155 dysregulation in hemodialysis patients.