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Updated: May 4, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Standardization of chemotherapy and individual dosing of platinum compounds
Florent Puisset1, Antonin Schmitt, Etienne Chatelut
1Institut Claudius-Regaud and EA4553, University of Toulouse, France. chatelut.etienne@claudiusregaud.fr.
Abstract:
Platinum compounds represent a pharmacological class essential for the treatment of certain types of cancer. Cisplatin, carboplatin, and oxaliplatin, share some physiochemical and pharmacological properties, in particular the ability to form DNA adducts. Carboplatin may be considered as an analog of cisplatin, but its pharmacokinetic properties, side-effects, and intrinsic activity are significantly different from those of cisplatin. The choice of one of these two compounds may be made rationally based on the individual patient's characteristics.
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