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Updated: May 4, 2026

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
Spindle cell carcinoma of the gingiva: A rare occurrence
Anjana Ramamurti1, Madhumathi Venkataraman1, Malathi Narasimhan2
1Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, Chennai, Tamil Nadu, India.
Abstract:
Of the many neoplasms known, squamous cell carcinoma (SCC) is the most common to affect the oral cavity. Spindle cell carcinoma (SpCC) is considered a rare high malignant variant of SCC occurring predominantly in the upper aerodigestive tract. Soft-tissue spindle cell neoplasms are quite uncommon in the oral cavity reportedly accounting for lesser than 1% of all tumors in the oral region. Our case shows an unusual presentation of SpCC involving the mandibular gingiva in a 46-year-old smoker patient, which presented as a firm, erythematous swelling with surface necrosis. An incisional biopsy was performed for microscopic evaluation to confirm the clinical diagnosis and for treatment planning.
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