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Related Concept Videos

Overview of Regeneration and Repair01:19

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Related Experiment Video

Updated: May 4, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling
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Invasive cervical root resorption: Engineering the lost tissue by regeneration.

Dexton Antony Johns1, Vasundara Yayathi Shivashankar1, Ramesh Kumar Maroli1

  • 1Department of Endodontics, Government Dental College, Calicut, Kerala, India.

Contemporary Clinical Dentistry
|January 10, 2014
PubMed
Summary

Early diagnosis and combined treatment of invasive cervical resorption (ICR) led to significant bone fill. This case report highlights a successful strategy for managing ICR, improving healing outcomes.

Keywords:
Invasive cervical resorptionplatelet rich fibrinsandwich restoration

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Area of Science:

  • Dentistry
  • Endodontics
  • Periodontics

Background:

  • Invasive cervical resorption (ICR) is a destructive process affecting the root surface and surrounding alveolar bone.
  • Successful management of ICR requires early diagnosis, resorption elimination, and effective restorative strategies.

Observation:

  • A case of ICR was treated with a multi-modal approach.
  • Treatment involved non-surgical root canal therapy, surgical exposure of the resorptive defect, and its restoration using the reverse sandwich technique.

Findings:

  • The bony defect was augmented with platelet-rich fibrin (PRF), hydroxylapatite, and a PRF membrane.
  • A significant bone fill was observed after a 2-year follow-up period, indicating successful regeneration.

Implications:

  • This combined therapeutic strategy may enhance healing outcomes for patients with invasive cervical resorption.
  • The findings suggest a promising approach for managing complex ICR cases, preserving tooth structure and supporting bone.