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Centrifugation

Centrifugation

Centrifugation is a separation technique based on differences in density or size. It is commonly used to separate solids from aqueous interferents. During centrifugation, the sample is placed in centrifugation tubes and spun at high angular velocity, which allows centrifugal force to act differentially on the different densities or masses of the components. After spinning, the supernatant liquid is decanted. Depending on the specific application, either the pellet or the supernatant is retained...

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Vortex-aided inertial microfluidic device for continuous particle separation with high size-selectivity, efficiency,

Xiao Wang¹, Jian Zhou¹, Ian Papautsky¹

¹BioMicroSystems Laboratory, School of Electronic and Computing Systems, University of Cincinnati, Cincinnati, Ohio 45221, USA.

Biomicrofluidics

|January 10, 2014

Summary

This study introduces a simple microfluidic device for efficiently separating large particles from smaller ones. The technology achieves high purity and selectivity, offering a novel approach for cell manipulation and separation.

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A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Area of Science:

Biotechnology
Microfluidics
Biomedical Engineering

Background:

Particle separation is crucial in various biological and medical applications.
Existing methods often face challenges with efficiency, purity, or complexity.

Purpose of the Study:

To develop a simple, efficient, and highly selective inertial microfluidic device for continuous particle extraction.
To demonstrate the device's capability in separating particles based on size.

Main Methods:

Utilized a high-aspect-ratio microchannel for inertial cell equilibration.
Incorporated symmetric chambers with microvortex-aided extraction.
Employed a design with a side outlet for larger particles and a main outlet for smaller ones.

Main Results:

Achieved continuous extraction of large particles with high size-selectivity (<2 μm).
Demonstrated high separation efficiency (∼90%) and purity (>90%).
The device is simple, has a small footprint, and allows for easy paralleling and cascading.

Conclusions:

The developed inertial microfluidic device offers a robust solution for continuous, ultra-selective particle separation.
This technology has broad applications in cell manipulation and purification processes.
The simple design and high performance make it a promising tool for various biotechnological applications.