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Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Translational Regulation01:29

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Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
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Related Experiment Video

Updated: May 4, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
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The Rockefeller University Navigation Program: a structured multidisciplinary protocol development and educational

Donna Brassil1, Rhonda G Kost, Kathleen A Dowd

  • 1The Rockefeller University Center for Clinical and Translational Science, 1230 York Avenue, New York, New York, USA.

Clinical and Translational Science
|January 11, 2014
PubMed
Summary
This summary is machine-generated.

The Navigation program streamlines translational research protocol development, ensuring ethical standards and accelerating Institutional Review Board (IRB) approval. This structured guidance enhances research integrity and facilitates investigator training.

Keywords:
FDAtranslational researchtrials

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Area of Science:

  • Clinical Research
  • Translational Science
  • Research Ethics

Background:

  • Translational clinical research protocol development is inherently complex.
  • Ensuring adherence to good clinical practice (GCP) standards, research ethics, and integrity is crucial.
  • Investigators often require structured support to navigate the protocol development process effectively.

Purpose of the Study:

  • To introduce and evaluate a structured supportive guidance process named Navigation.
  • To expedite the development of translational clinical research protocols to GCP standards.
  • To focus on enhancing research ethics and integrity throughout protocol development.

Main Methods:

  • The Navigation process involves experienced research coordinators guiding investigators through multistep protocol development.
  • Data collected include investigator experience, support intensity, Institutional Review Board (IRB) review outcomes, and protocol timelines.
  • The study analyzed 144 protocols navigated since 2007 across various investigator credentials.

Main Results:

  • Over 50% of Navigated protocols received IRB approval within 30 days annually.
  • Navigation facilitated the approval of 144 protocols, including those led by trainee investigators.
  • Trainee investigators required less Navigation support with subsequent protocols, indicating a learning curve.

Conclusions:

  • Navigation effectively accelerates the development and approval of high-quality, ethical translational research protocols.
  • The program increases access to translational research for basic scientists.
  • Navigation serves as a valuable tool for good clinical practice (GCP) training and protocol optimization.