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Intralobar pulmonary sequestration complicating with cryptococcal infection

Chao Guan1, Hui Chen, Changzhou Shao

  • 1Shanghai Institute of Respiratory Diseases, Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

The Clinical Respiratory Journal
|January 11, 2014
PubMed
Abstract

Insights

Pulmonary sequestration, a rare lung malformation, can complicate with fungal infections like cryptococcosis. This case highlights the importance of considering this rare cause in persistent pulmonary cryptococcal infections.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Congenital Malformations

Background:

  • Pulmonary sequestration is a rare congenital lung malformation involving aberrant systemic arterial supply.
  • It commonly presents with recurrent infections, but fungal infections are exceptionally rare.

Observation:

  • A 20-year-old immunocompetent male presented with ocular and pulmonary symptoms suggestive of cryptococcosis.
  • Initial treatment with antibiotics and steroids was ineffective, necessitating further investigation.

Findings:

  • Diagnosis confirmed cryptococcal infection in both the lung and eye.
  • Surgical resection revealed underlying pulmonary sequestration, a previously unreported association.
  • Literature review found no prior reports of pulmonary sequestration complicating cryptococcal infection.

Implications:

  • Pulmonary sequestration should be considered as a potential underlying cause in cryptococcal lung infections, especially in recurrent or treatment-resistant cases.
  • Early diagnosis and appropriate management, potentially including surgical intervention, are crucial for favorable outcomes.
Keywords:
cryptococcosisendophthalmitislobectomypulmonary sequestration

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