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"Stress entropic load" as a transgenerational epigenetic response trigger.

Julie Bienertová-Vašků1, Ivo Nečesánek2, Jan Novák2

  • 1Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno 625 00, Czech Republic; Department of Paediatric Oncology, University Hospital Brno, Brno 613 00, Czech Republic; Central-European Technological Institute, Brno, Czech Republic; Regional Centre for Applied Molecular Oncology, Brno, Czech Republic.

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Summary

Stress adaptation cost may trigger transgenerational epigenetic inheritance. We propose "stress entropic load" quantifies this energy cost, potentially predicting inherited traits.

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Area of Science:

  • Epigenetics and Molecular Biology
  • Systems Biology
  • Evolutionary Biology

Background:

  • Epigenetic modifications regulate gene expression during development and adaptation.
  • The mechanisms determining which epigenetic information is reset or transmitted across generations remain unclear.
  • Meiosis is a key process where epigenetic information is selectively resolved or passed on.

Purpose of the Study:

  • To investigate the trigger for transgenerational epigenetic inheritance.
  • To propose a theoretical framework explaining the transmission of acquired traits.
  • To identify a quantifiable measure for predicting epigenetic transgenerational response.

Main Methods:

  • Theoretical proposal linking stress adaptation energy cost to epigenetic transmission.
  • Review of existing literature on entropy generation, stress, and biological systems.
  • Conceptualization of a new metric: "stress entropic load".

Main Results:

  • Stress adaptation, specifically its energetic cost, is proposed as a trigger for transgenerational epigenetic inheritance.
  • Higher lifetime entropy generation correlates with increased stress and organ degradation.
  • The proposed "stress entropic load" reflects the energetic cost of adaptation.

Conclusions:

  • The energy cost of adapting to stress is a viable candidate for triggering the transgenerational transmission of epigenetic information.
  • "Stress entropic load" offers a potential metric to quantify this cost and estimate the probability of inducing a transgenerational response.
  • Understanding stress entropic load may elucidate the inheritance of acquired traits and adaptation mechanisms.