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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

726
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
726
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

784
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
784
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

674
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Histology of the Small Intestine01:27

Histology of the Small Intestine

3.0K
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
3.0K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

539
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
539
Histology of the Large Intestine01:26

Histology of the Large Intestine

2.5K
The large intestine, a vital component of the gastrointestinal tract, is structured with four main layers: the mucosa, submucosa, muscularis, and serosa. Each layer performs a distinct role in facilitating the smooth functioning of the large intestine.
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
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Related Experiment Videos

Microscopic colitis: clinical and pathologic perspectives.

Andreas Münch1, Cord Langner2

  • 1Division of Gastroenterology and Hepatology, Department of Clinical and Experimental Medicine, Faculty of Health Science, Linköpings University, Linköping, Sweden.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|January 11, 2014
PubMed
Summary
This summary is machine-generated.

Microscopic colitis, an under-recognized inflammatory bowel disease, causes chronic diarrhea and impacts quality of life. This review covers its features, pathogenesis, diagnosis, and treatment, including budesonide-refractory options.

Keywords:
ColonEMCGImmune ResponseTherapy

Related Experiment Videos

Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease Research
  • Colitis Studies

Background:

  • Microscopic colitis is a chronic inflammatory bowel disease presenting with chronic nonbloody diarrhea.
  • Its incidence and prevalence rival Crohn's disease and ulcerative colitis, yet it remains under-recognized.
  • Etiology, pathophysiology, diagnosis, and treatment present significant clinical challenges.

Purpose of the Study:

  • To review the epidemiology and clinical features of microscopic colitis.
  • To discuss the pathogenesis and histopathologic evaluation criteria.
  • To outline current treatment algorithms and options for refractory cases.

Main Methods:

  • Literature review of epidemiologic and clinical features.
  • Discussion of pathogenesis based on current understanding.
  • Outline of European Consensus histopathologic criteria and treatment algorithm.

Main Results:

  • Microscopic colitis significantly reduces quality of life due to active disease symptoms.
  • Under-recognition stems from limited knowledge of its etiology and pathophysiology among healthcare workers.
  • Established diagnostic criteria and treatment algorithms exist, with options for budesonide-refractory disease.

Conclusions:

  • Microscopic colitis is a significant condition comparable to other IBDs, requiring greater clinical recognition.
  • Understanding pathogenesis and adhering to standardized histopathologic criteria are crucial for diagnosis.
  • A structured approach to treatment, including options for refractory cases, is essential for patient management.