Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac remodelling and dysfunction in cancer patients receiving cardiotoxic therapies: proteomic and metabolomic profiling.

European heart journal·2026
Same author

Simultaneous Prenatal cfDNA Screening of Aneuploidy, Recessive Single-Gene Conditions, and Fetomaternal Blood Compatibility.

Clinical chemistry·2026
Same author

Complement activation in a phase Ib study of fordadistrogene movaparvovec for Duchenne muscular dystrophy.

Molecular therapy : the journal of the American Society of Gene Therapy·2025
Same author

Integrating electrocardiogram and fundus images for early detection of cardiovascular diseases.

Scientific reports·2025
Same author

Deciphering the role of exosomal derived regulatory noncoding RNAs as potential biomarkers for diabetic retinopathy: a systematic review.

International journal of retina and vitreous·2024
Same author

RNA Isoform Diversity in Human Neurodegenerative Diseases.

eNeuro·2024
Same journal

From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians.

Clinical chemistry·2026
Same journal

Interlaboratory Comparison of a Glucagon and Oxyntomodulin Immuno-LC-MS/MS Assay: Implications for Diabetes Research.

Clinical chemistry·2026
Same journal

Comparison of Information-Dependent Acquisition and Sequential Window Acquisition of All Theoretical Mass Spectra for Untargeted Drug Testing on a Linear Ion Trap-Pulsing Quadrupole-Time of Flight Mass Spectrometer.

Clinical chemistry·2026
Same journal

Patterns of One-Year Change in HbA1c and Continuous Glucose Monitoring (CGM) Metrics in Older Adults with Type 2 Diabetes.

Clinical chemistry·2026
Same journal

TSH Pediatric Reference Intervals: Lack of CALIPER Applicability to US-Based Populations.

Clinical chemistry·2026
Same journal

Rapid Detection of Hemoglobinopathy Variants Using One-Step Library Preparation and Nanopore Sequencing.

Clinical chemistry·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

8.1K

Noninvasive micromarkers.

Janani Saikumar1, Krithika Ramachandran1, Vishal S Vaidya2

  • 1Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and Department of Environmental Health, Harvard School of Public Health, Boston, MA.

Clinical Chemistry
|January 11, 2014
PubMed
Summary
This summary is machine-generated.

Cell-free microRNAs (miRNAs) are promising noninvasive biomarkers for various diseases. Research explores their protective mechanisms, extracellular presence, and diagnostic potential across numerous conditions.

More Related Videos

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults

Published on: February 8, 2019

5.9K
Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury
07:28

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

Published on: March 24, 2023

3.9K

Related Experiment Videos

Last Updated: May 4, 2026

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

8.1K
Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults

Published on: February 8, 2019

5.9K
Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury
07:28

Author Spotlight: Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

Published on: March 24, 2023

3.9K

Area of Science:

  • Molecular Biology
  • Genomics
  • Biomarker Discovery

Background:

  • Genome-wide sequencing advances enable discovery of small RNA (sRNA) classes as disease indicators.
  • Cell-free microRNAs (miRNAs) are stable in body fluids, reflecting physiological states and serving as noninvasive biomarkers.
  • Extracellular miRNAs are investigated as biomarkers for cancers, organ damage, and diverse diseases.

Purpose of the Study:

  • To summarize mechanisms of miRNA protection and release.
  • To compile literature on extracellular miRNAs as biomarkers for various diseases.
  • To discuss miRNA biomarker discovery workflows and challenges.

Main Methods:

  • Literature review and synthesis of existing research on extracellular miRNAs.
  • Analysis of studies investigating miRNA expression profiles in disease states.
  • Critical evaluation of the miRNA biomarker discovery pipeline.

Main Results:

  • Extracellular miRNAs have been identified as potential biomarkers for 20 cancers, 11 organ damage conditions, and 10 other disease states.
  • Understanding of miRNA protection and release mechanisms is evolving.
  • Various strategies exist for miRNA biomarker discovery.

Conclusions:

  • MiRNA diagnostics are emerging, with ongoing research into their pathophysiological roles and release mechanisms.
  • Extracellular miRNAs hold significant potential in translational medicine for diagnosis, risk assessment, and treatment guidance.
  • Further research is needed to overcome current challenges in the field.