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Oxidative stress induces gastric submucosal arteriolar dysfunction in the elderly
1Lei Liu, Jie Cui, Wei-Li Qiao, Hong Sun, Chang-Dong Yan, Department of Physiology, Xuzhou Medical College, Xuzhou 221004, Jiangsu Province, China.
World Journal of Gastroenterology
|January 11, 2014
Summary
Aging impairs gastric submucosal blood vessels, increasing oxidative stress and reducing antioxidant defenses. This study reveals age-related vascular dysfunction in the stomach, impacting blood flow regulation.
Area of Science:
- Gastroenterology
- Vascular Biology
- Aging Research
Background:
- Gastric submucosal vascular function can be affected by aging.
- Understanding age-related changes in gastric vasculature is crucial for gastrointestinal health.
- Oxidative stress and antioxidant capacity play roles in vascular aging.
Purpose of the Study:
- To investigate human gastric submucosal vascular dysfunction in aging.
- To elucidate the underlying mechanisms of age-related gastric vascular changes.
Main Methods:
- Compared gastric submucosal arteries from young (25-40 years) and elderly (60-85 years) male patients.
- Assessed vascular responses to acetylcholine and sodium nitroprusside via isolated perfusion.
- Analyzed morphological changes and quantified oxidative stress markers (xanthine oxidase, malondialdehyde) and antioxidant defenses (manganese-superoxide dismutase, superoxide dismutase, glutathione peroxidase).
Main Results:
- Elderly patients showed increased vessel wall cell layers, collagen, lumen diameter, and media cross-sectional area.
- Gastric arterioles in the elderly exhibited reduced vasodilatation responses to acetylcholine and sodium nitroprusside.
- Increased oxidative stress markers (xanthine oxidase, malondialdehyde, hydrogen peroxide) and decreased antioxidant markers (manganese-superoxide dismutase, superoxide dismutase, glutathione peroxidase) were observed in elderly gastric arterioles.
Conclusions:
- Gastric vascular dysfunction in aging is linked to heightened oxidative stress.
- Diminished antioxidative defense mechanisms contribute to gastric vascular senescence.
- These findings highlight the impact of aging on gastric microcirculation and its potential health implications.
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