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Related Experiment Video

Updated: May 4, 2026

RNA Fluorescence in situ Hybridization FISH to Visualize Microbial Colonization and Infection in Caenorhabditis elegans Intestines

RNA Fluorescence in situ Hybridization FISH to Visualize Microbial Colonization and Infection in Caenorhabditis elegans Intestines

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Debug Your Bugs - How NLRs Shape Intestinal Host-Microbe Interactions.

Simone Lipinski¹, Philip Rosenstiel¹

¹Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel , Kiel , Germany.

Frontiers in Immunology

|January 11, 2014

Summary

This summary is machine-generated.

NOD-like receptors (NLRs) are key regulators of the gut microbiome and host health. Dysfunctional NLRs can lead to intestinal inflammation and immune-mediated diseases.

Keywords:

Crohn disease NLR gut microbiota inflammation intestinal mucosa mucosal immunity symbiosis

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Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Visualization of Gut Microbiota-host Interactions via Fluorescence In Situ Hybridization, Lectin Staining, and Imaging

Published on: July 9, 2021

Area of Science:

Immunology
Microbiology
Gastroenterology

Background:

Host-microbe interactions are vital for intestinal homeostasis.
NOD-like receptors (NLRs) are crucial mediators of these interactions.
NLRs monitor microbial activity at the intestinal barrier.

Purpose of the Study:

To review advances in understanding the relationship between NLRs and intestinal homeostasis.
To explore the implications of this relationship for intestinal health.

Main Methods:

Literature review of recent research on NLRs and intestinal host-microbe interactions.

Main Results:

NLRs play a central role in discriminating between beneficial and harmful microbes.
Dysfunctional NLRs are linked to intestinal inflammation and altered gut microbiota.
NLR dysfunction can contribute to extra-intestinal immune-mediated diseases.

Conclusions:

NLRs are critical for maintaining intestinal homeostasis.
Understanding NLR function is essential for addressing inflammatory and immune-mediated diseases of the gut.