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Asthma I: Introduction01:28

Asthma I: Introduction

112
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.3K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Allergic Reactions02:06

Allergic Reactions

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Overview
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Related Experiment Video

Updated: May 4, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

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Allergic asthma biomarkers using systems approaches.

Gaurab Sircar1, Bodhisattwa Saha1, Swati G Bhattacharya1

  • 1Division of Plant Biology, Bose Institute Kolkata, India.

Frontiers in Genetics
|January 11, 2014
PubMed
Summary

This review explores new biomarkers for allergic asthma, focusing on molecules identified through genomic and proteomic studies. These biomarkers could aid in diagnosing and treating asthma using systems biology approaches.

Keywords:
DAABTH-2 cytokines and ROS pathwayallergic asthmabiomarker

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Area of Science:

  • * Pulmonology and Immunology
  • * Biomarker Discovery
  • * Systems Biology

Background:

  • * Asthma involves lung inflammation from immune responses to environmental factors like allergens and pollutants.
  • * Identifying reliable biomarkers is crucial for understanding and managing asthma.
  • * Current research focuses on molecular signatures linked to asthma development and progression.

Purpose of the Study:

  • * To review updated research on biomarkers associated with allergic asthma.
  • * To explore the potential of these biomarkers in systems biology approaches to asthma.
  • * To highlight biomolecules with altered expression relevant for diagnosis and therapy.

Main Methods:

  • * Analysis of genomic, proteomic, and epigenomic data from human and experimental asthma models.
  • * Utilizing high-throughput technologies like microarrays and Mass Spectrometry (MS).
  • * Reviewing studies identifying gene and protein expression profiles related to asthma.

Main Results:

  • * Identification of various biomolecules with altered expression serving as potential inflammatory, diagnostic, and therapeutic biomarkers.
  • * Summary of pathways significantly linked to asthma pathophysiology based on compiled biomarkers.
  • * Demonstration of how systems approaches can reveal regulatory networks for biomarker identification.

Conclusions:

  • * Altered biomolecules show promise as key biomarkers for asthma diagnostics and therapeutics.
  • * Systems biology approaches integrating multi-omics data can uncover critical regulatory networks.
  • * Further research using these biomarkers can advance personalized medicine and drug discovery for asthma.