Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

mHealth-Enabled Stroke Screening for Pediatric Sickle Cell Disease in Low-Resource Settings: Systematic Literature Review of Critical Barriers, Emerging Technologies, and AI-Driven Solutions.

JMIR pediatrics and parenting·2026
Same author

How sensitive is the reduced scattering coefficient to changes in specific micro-scale biophysical properties of tissue scatterers?

Optics letters·2026
Same author

Accuracy of intraoperative cholangiography and outcomes of ERCP in hospitalized patients with suspected choledocholithiasis.

iGIE : innovation, investigation and insights·2026
Same author

Short-wave infrared (SWIR) spectroscopy and imaging of biological tissues: a decade of advancements (2016-2025).

Journal of biomedical optics·2025
Same author

Feeding from the sun-Successes and prospects in bioengineering photosynthesis for food security.

Cell·2025
Same author

Targeting FSP1 triggers ferroptosis in lung cancer.

Nature·2025

Related Experiment Video

Updated: May 4, 2026

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

10.4K

Characterizing human pancreatic cancer precursor using quantitative tissue optical spectroscopy.

Seung Yup Lee1, William R Lloyd1, Malavika Chandra2

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2099, USA.

Biomedical Optics Express
|January 11, 2014
PubMed
Summary

Optical spectroscopy can differentiate pre-cancerous pancreatic neoplasms from normal tissue. This pilot study used a photon-tissue interaction model to analyze cellular and collagen characteristics, showing potential for early cancer detection.

Keywords:
(170.4580) Optical diagnostics for medicine(170.6510) Spectroscopy, tissue diagnostics

More Related Videos

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

20.2K
Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
15:18

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research

Published on: January 12, 2013

18.1K

Related Experiment Videos

Last Updated: May 4, 2026

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
10:58

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

10.4K
Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

20.2K
Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research
15:18

Near Infrared Optical Projection Tomography for Assessments of β-cell Mass Distribution in Diabetes Research

Published on: January 12, 2013

18.1K

Area of Science:

  • Biomedical Optics
  • Gastroenterology
  • Oncology

Background:

  • Intraductal papillary mucinous neoplasm (IPMN) is a common precursor to pancreatic cancer.
  • Early detection of IPMN is crucial for preventing pancreatic cancer progression.

Purpose of the Study:

  • To evaluate the potential of multimodal optical spectroscopy for distinguishing IPMN from normal pancreatic tissue.
  • To explore the use of quantitative tissue-optics models in characterizing neoplastic changes.

Main Methods:

  • A pilot study utilized multimodal optical spectroscopy on freshly excised human pancreatic tissues.
  • A photon-tissue interaction (PTI) model was employed to analyze reflectance and fluorescence spectra.
  • Parameters extracted included cellular nuclear size, refractive index, and extracellular collagen content.

Main Results:

  • Optical spectroscopy successfully differentiated IPMN from normal pancreatic tissues.
  • The PTI model effectively extracted parameters related to tissue composition and cellular morphology.
  • Specific spectral features correlated with neoplastic changes in pancreatic tissue.

Conclusions:

  • Multimodal optical spectroscopy shows promise for characterizing pre-cancerous pancreatic neoplasms.
  • This technique offers a potential non-invasive method for early detection and diagnosis of IPMN.
  • Further research is warranted to validate these findings in clinical settings.