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Evaluation of pneumococcal PCR and urinary antigen detection in children
Aslinur Ozkaya Parlakay1, Mehmet Ceyhan2, Melda Celik2
1Hacettepe University Pediatric Infectious Diseases Department, Ankara, Turkey. aslinur.o@gmail.com
Background:
The rapid detection of Streptococcus pneumoniae could assist in the management of pneumococcal infections. The Binax NOW S. pneumoniae test is a rapid immunochromatographic test for this purpose.
Methods:
Multiplex PCR in parapneumonic pleural effusion fluid (PPEF) and cerebrospinal fluid (CSF) with Binax NOW urinary pneumococcal antigen test (PAT) from 80 children was compared in this study.
Results:
PAT had a sensitivity of 36.4%, specificity of 97.3%, in CSF. PAT had a sensitivity of 50%, specificity of 81% for parapneumonic pleural effusion fluid.
Conclusions:
When rapid management of a serious infection is needed the Binax NOW test could be a reliable method for the exclusion of S. pneumoniae infection.
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