Related Experiment Video

Updated: May 4, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model
07:40

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

5.3K

Disease of the year: juvenile idiopathic arthritis-associated uveitis--classification and diagnostic approach

Ilknur Tugal-Tutkun1, Pierre Quartier, Bahram Bodaghi

  • 1Department of Ophthalmology, Istanbul University, Istanbul Faculty of Medicine , Istanbul , Turkey .

Ocular Immunology and Inflammation
|January 14, 2014
PubMed

Insights

Juvenile idiopathic arthritis (JIA) is a common childhood rheumatic disease. Specific JIA subtypes, like ANA-positive oligoarticular JIA, carry a higher risk for chronic uveitis, while enthesitis-related arthritis presents with acute iridocyclitis.

Area of Science:

  • Pediatric Rheumatology
  • Ophthalmology
  • Genetics

Background:

  • Juvenile idiopathic arthritis (JIA) is the most prevalent chronic rheumatic condition in children.
  • JIA is associated with uveitis, an inflammatory eye condition, with varying risks across its subtypes.
  • The International League of Associations for Rheumatology (ILAR) classification system defines seven JIA subtypes.

Purpose of the Study:

  • To outline the classification and ocular manifestations of Juvenile idiopathic arthritis (JIA).
  • To identify risk factors for uveitis within different JIA subtypes.
  • To discuss diagnostic approaches and emerging genetic insights for JIA.

Main Methods:

  • Review of existing literature on JIA classification and uveitis.
  • Analysis of ocular involvement patterns in different JIA subtypes.
  • Summary of diagnostic criteria and laboratory investigations for JIA.

Main Results:

  • Systemic JIA and juvenile-onset rheumatoid arthritis rarely present with uveitis.
  • Early-onset antinuclear antibody (ANA)-positive oligoarticular JIA shows the highest risk for chronic iridocyclitis.
  • Enthesitis-related arthritis is linked to recurrent acute symptomatic iridocyclitis.

Conclusions:

  • Accurate JIA classification is crucial for predicting ocular complications like uveitis.
  • Diagnostic workup for JIA involves clinical assessment, serological tests (ANA, RF, HLA-B27), and imaging.
  • Gene expression profiling shows promise for improving JIA diagnosis, classification, and patient management.

More Related Videos

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

4.3K
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.8K

Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
842
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
409
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.3K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K