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Updated: May 4, 2026

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Published on: July 25, 2020
Integrating pharmacogenomics into oncology clinical practice
Sharon Marsh1, Michael S Phillips
1Washington University in St Louis, Division of Oncology, 660 South Euclid Ave - Campus Box 8069, St Louis, MO 63110, USA. smarsh@im.wustl.edu.
Advances in oncology pharmacogenomics are driven by human genome data and genotyping. These developments support targeted cancer therapies and clinical trial integration for personalized medicine.
Area of Science:
- Genomic Medicine
- Pharmacogenomics
- Oncology
Background:
- Significant advancements in oncology pharmacogenomics over the last decade.
- Availability of Human Genome Project data and cost-effective genotyping platforms.
- Expansion of pharmacogenomics research with invaluable data.
Purpose of the Study:
- To review the progress and integration of pharmacogenomics in clinical oncology practice.
- Highlight key developments enabling personalized cancer therapy.
Main Methods:
- Review of recent progress in oncology pharmacogenomics.
- Analysis of key milestones including targeted therapies, package insert changes, and clinical trials.
- Examination of diagnostic panels for DNA and expression markers.
Main Results:
- Introduction of FDA-approved targeted therapies like trastuzumab.
- Package insert updates for irinotecan and tamoxifen based on genetic markers.
- Initiation of genotype-guided clinical trials, such as TYMS TSER for rectal cancer.
- Development of comprehensive diagnostic panels (e.g., Roche AmpliChip, Oncotype Dx).
Conclusions:
- Pharmacogenomic advancements are paving the way for integration into routine clinical practice.
- Personalized medicine approaches are becoming increasingly feasible in oncology.
- Genotype-guided therapies and diagnostic tools are transforming cancer treatment.
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