Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.5K
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

49
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
49
Asthma I: Introduction01:28

Asthma I: Introduction

112
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
112
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Italian multicentre study on the management of pLeural infection and empyema: IMPLE study.

Respiratory research·2025
Same author

Reply to Correspondence: The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper.

Allergy·2025
Same author

Raising the bar in respiratory care by EUFOREA: report of the European Union Parliament Symposium, April 2024.

Frontiers in allergy·2025
Same author

[Impact of Rac1 activation on eosinophil degranulation in severe asthma].

Revue des maladies respiratoires·2025
Same author

Auto-antibodies against carbonyl-modified vimentin in COPD: potential role as a biomarker.

Journal of inflammation (London, England)·2025
Same author

The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper.

Allergy·2024

Related Experiment Video

Updated: May 4, 2026

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

1.8K

EAACI position statement on asthma exacerbations and severe asthma.

A Custovic1, S L Johnston, I Pavord

  • 1Centre Lead for Respiratory Medicine, Institute of Inflammation & Repair, University of Manchester, University Hospital of South Manchester, Manchester, UK.

Allergy
|January 14, 2014
PubMed
Summary

Asthma exacerbations and severe asthma require better treatment strategies. Current guidelines fall short, necessitating increased awareness and novel approaches for difficult-to-treat asthma patients.

Keywords:
adult asthmaasthma exacerbationschildhood asthmadisease heterogeneitysevere asthma

More Related Videos

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.6K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

34.4K

Related Experiment Videos

Last Updated: May 4, 2026

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

1.8K
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

1.6K
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

34.4K

Area of Science:

  • Allergy and Clinical Immunology
  • Respiratory Medicine
  • Immunology

Background:

  • Asthma exacerbations and severe asthma are associated with significant morbidity, mortality, and healthcare costs.
  • Recurrent exacerbations lead to lung function decline and persistent asthma development in children.
  • Current treatment guidelines inadequately address frequent exacerbations and severe, treatment-resistant asthma.

Purpose of the Study:

  • To highlight shortcomings in existing asthma treatment guidelines.
  • To advocate for increased awareness of asthma exacerbation severity.
  • To emphasize the need for novel treatment strategies for severe, treatment-resistant asthma.

Main Methods:

  • Review of current evidence on asthma exacerbations and severe asthma.
  • Analysis of factors contributing to exacerbations, including viral infections, innate immunity, and allergic mechanisms.
  • Discussion of nonadherence, environmental factors, and psychosocial influences in difficult-to-control asthma.

Main Results:

  • Strong evidence links asthma exacerbations to viral infections, innate immunity deficiencies, and synergistic effects with allergic mechanisms.
  • Medication nonadherence is a common issue in difficult-to-control asthma.
  • Modifiable factors like smoking, allergen exposure, and psychosocial issues require clinical prioritization.

Conclusions:

  • Current asthma guidelines need revision to better manage frequent exacerbations and severe, treatment-resistant cases.
  • Increased awareness of exacerbation seriousness and the need for new treatments is crucial.
  • Further research with advanced tools is essential to understand asthma pathophysiology and heterogeneity.