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Updated: May 4, 2026

Imaging the Intracellular Trafficking of APP with Photoactivatable GFP
Published on: October 17, 2015
Trafficking regulation of proteins in Alzheimer's disease
Shangtong Jiang, Yanfang Li, Xian Zhang
1Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian 361102, China. yunzhang@xmu.edu.cn.
Abstract:
The β-amyloid (Aβ) peptide has been postulated to be a key determinant in the pathogenesis of Alzheimer's disease (AD). Aβ is produced through sequential cleavage of the β-amyloid precursor protein (APP) by β- and γ-secretases. APP and relevant secretases are transmembrane proteins and traffic through the secretory pathway in a highly regulated fashion. Perturbation of their intracellular trafficking may affect dynamic interactions among these proteins, thus altering Aβ generation and accelerating disease pathogenesis. Herein, we review recent progress elucidating the regulation of intracellular trafficking of these essential protein components in AD.
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