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Updated: May 4, 2026

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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The bile acid TGR5 membrane receptor: from basic research to clinical application

Henri Duboc1, Yvette Taché2, Alan F Hofmann3

  • 1Department of Medicine, CURE/Digestive Diseases Center and Center for Neurobiology of Stress, Digestive Diseases Division, University of California at Los Angeles, Los Angeles, CA, USA; Veterans Affairs Greater Los Angeles Healthcare System, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; University Paris Diderot, Sorbonne Paris Cité, AP-HP, Louis Mourier Hospital, Department of Gastroenterology and Hepatology, Paris, France; University Pierre and Marie Curie, ERL INSERM U 1057/UMR 7203, AP-HP, Saint-Antoine Hospital, Paris, France.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|January 14, 2014
PubMed
Summary

The TGR5 receptor, activated by bile acids, plays a role in energy balance and intestinal function. Its widespread expression suggests involvement in metabolic diseases like obesity and diabetes.

Keywords:
Bile acidsDiabetesInflammationMotilityTGR5 receptor

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