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The function of BAFF on T helper cells in autoimmunity
Maogen Chen1, Xiaohong Lin2, Ya Liu3
1Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China; Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
Cytokine & Growth Factor Reviews
|January 14, 2014
Summary
B cell-activating factor (BAFF) supports B cell survival and proliferation, but also activates T cells. This review discusses BAFF
Area of Science:
- Immunology
- Molecular Biology
Background:
- B cell-activating factor belonging to the TNF family (BAFF) is crucial for B cell survival, proliferation, and autoreactivity.
- Overexpression of BAFF leads to B cell expansion, autoantibody production, and immune complex deposition.
Purpose of the Study:
- To review recent advancements in understanding BAFF's function and role in T cells.
- To explore the impact of BAFF on T cell-mediated diseases.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of studies investigating BAFF's effects on T cell activation, proliferation, and differentiation.
Main Results:
- BAFF not only influences B cells but also promotes T cell activation, proliferation, and differentiation.
- Recent research highlights BAFF's broader role beyond B cell regulation.
Conclusions:
- BAFF plays a significant role in T cell responses.
- Further research into BAFF's function in T cell-mediated diseases is warranted.
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