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Updated: May 4, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
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Synaptic plasticity and the Warburg effect.

Pierre J Magistretti1

  • 1Brain Mind Institute, EPFL, Station 19, CH-1015 Lausanne, Switzerland; Center for Psychiatric Neuroscience, CHUV-UNIL, CH-1008 Prilly-Lausanne, Switzerland; Division of Biological and Environmental Sciences and Engineering, KAUST, Thuwal 23955-6900, Kingdom of Saudi Arabia.

Cell Metabolism
|January 14, 2014
PubMed
Summary
This summary is machine-generated.

Certain brain regions show aerobic glycolysis, where glucose use outpaces oxygen consumption. This metabolic state correlates with increased gene expression for synaptic plasticity and brain remodeling.

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Area of Science:

  • Neuroscience
  • Neurobiology
  • Brain Metabolism

Background:

  • Functional brain imaging reveals distinct metabolic profiles in specific brain regions.
  • Aerobic glycolysis, characterized by higher glucose utilization than oxygen consumption, is observed in certain neural areas.

Purpose of the Study:

  • To investigate the relationship between aerobic glycolysis and gene expression in the brain.
  • To explore the molecular underpinnings of brain regions exhibiting a high rate of aerobic glycolysis.

Main Methods:

  • Analysis of functional brain imaging data to identify regions with predominant aerobic glycolysis.
  • Gene expression profiling in identified brain regions.

Main Results:

  • A significant association was found between aerobic glycolysis and gene expression patterns.
  • Enrichment of genes involved in synaptic plasticity and remodeling processes was observed in brain regions with high aerobic glycolysis.

Conclusions:

  • The metabolic profile of aerobic glycolysis in specific brain regions is linked to enhanced synaptic plasticity and remodeling.
  • This suggests a potential role for aerobic glycolysis in supporting neuronal function and adaptation.