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Updated: May 4, 2026

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
Published on: February 10, 2020
Two cases of traumatic head injury mimicking acute encephalopathy with biphasic seizures and late reduced diffusion
Masahiro Nishiyama1, Kyoko Fujita1, Azusa Maruyama1
1Department of Neurology, Hyogo Prefectural Kobe Children's Hospital, Japan.
Abstract:
Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) presents a distinct clinical course of biphasic seizures and impaired consciousness. These symptoms are followed by reduced diffusion in the subcortical white matter on magnetic resonance imaging that is typically observed between 3 and 9 days after illness onset. Here, we report two cases of traumatic head injury with clinical and radiological features similar to those for AESD. The similarities between our cases and AESD may be useful in understanding the pathogenesis of AESD.
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