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Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
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Gastritis can stem from various causes, each...
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Related Experiment Video

Updated: May 4, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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[Intracardiac thrombosis during celiac disease].

N Ghannouchi Jaafoura1, A Atig1, A Bouker1

  • 1Service de médecine interne, CHU Farhat-Hached, 4000 Sousse, Tunisie.

Journal Des Maladies Vasculaires
|January 14, 2014
PubMed
Summary

Celiac disease can cause unusual blood clots, including in the heart. This case highlights a rare intracardiac thrombus linked to celiac disease and protein deficiencies.

Keywords:
Celiac diseaseIntracardiac thrombusMaladie cœliaqueMyxomaMyxomeThrombophiliaThrombophilieThrombus intracardiaque

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Area of Science:

  • Cardiology
  • Gastroenterology
  • Hematology

Background:

  • Celiac disease is associated with thrombotic events, often in unusual locations like hepatic veins.
  • Poor adherence to a gluten-free diet in celiac disease patients can exacerbate complications.

Observation:

  • A 32-year-old male with celiac disease presented with an ischemic stroke.
  • Radiological imaging revealed an intracardiac thrombus mimicking a cardiac myxoma.
  • Histological examination confirmed the intracardiac thrombus.

Findings:

  • The patient exhibited severe protein C and S deficiency.
  • The intracardiac thrombus was diagnosed in a patient with poorly controlled celiac disease.
  • This represents the first reported case of intracardiac thrombosis in a celiac disease patient.

Implications:

  • This case underscores the importance of considering thrombotic complications in celiac disease, even in unusual locations.
  • Management involves addressing both the underlying celiac disease with a gluten-free diet and the thrombotic event with anticoagulation.
  • Severe protein C and S deficiency may be a contributing factor to thrombosis in celiac disease.