[Intracardiac thrombosis during celiac disease]

Area of Science:

• Cardiology
• Gastroenterology
• Hematology

Background:

• Celiac disease is associated with thrombotic events, often in unusual locations like hepatic veins.
• Poor adherence to a gluten-free diet in celiac disease patients can exacerbate complications.

Observation:

• A 32-year-old male with celiac disease presented with an ischemic stroke.
• Radiological imaging revealed an intracardiac thrombus mimicking a cardiac myxoma.
• Histological examination confirmed the intracardiac thrombus.

Findings:

• The patient exhibited severe protein C and S deficiency.
• The intracardiac thrombus was diagnosed in a patient with poorly controlled celiac disease.
• This represents the first reported case of intracardiac thrombosis in a celiac disease patient.

Implications:

• This case underscores the importance of considering thrombotic complications in celiac disease, even in unusual locations.
• Management involves addressing both the underlying celiac disease with a gluten-free diet and the thrombotic event with anticoagulation.
• Severe protein C and S deficiency may be a contributing factor to thrombosis in celiac disease.