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Related Experiment Video

Updated: May 4, 2026

An Electroporation Method to Transform Rickettsia spp. with a Fluorescent Protein-Expressing Shuttle Vector in Tick Cell Lines

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Published on: October 11, 2022

Rickets.

Charlotte Jane Elder¹, Nicholas J Bishop¹

¹University of Sheffield, Academic Unit of Child Health, Sheffield Children's Hospital, Western Bank, Sheffield, UK.

Lancet (London, England)

|January 14, 2014

Summary

This summary is machine-generated.

Rickets, a global bone disease, is primarily caused by insufficient vitamin D leading to low phosphate levels. Current infant vitamin D guidelines are unclear and need revision to prevent this condition.

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Area of Science:

Pediatrics
Nutritional Science
Endocrinology

Background:

Rickets, historically known as 'the English disease,' remains a prevalent global health issue.
The primary cause is inadequate vitamin D, leading to phosphate deficiency at growth plates and bone surfaces.
Inherited disorders affecting phosphate metabolism highlight the complexity of mineral homeostasis.

Purpose of the Study:

To address the inconsistencies and lack of clarity in current vitamin D supplementation guidelines for infants.
To emphasize the need for revised recommendations to effectively combat the widespread incidence of rickets.

Main Methods:

Review of existing literature on rickets etiology and vitamin D metabolism.
Analysis of current global infant feeding and vitamin D supplementation guidelines.
Evaluation of the impact of phosphate availability on bone mineralization.

Main Results:

Inadequate vitamin D supply is the principal driver of rickets worldwide.
Existing infant vitamin D guidance is fragmented, contradictory, and insufficient for disease eradication.
Understanding phosphate metabolism is crucial for addressing rickets pathogenesis.

Conclusions:

Current vitamin D recommendations for infants require significant clarification and revision.
A unified and evidence-based approach to vitamin D provision is necessary to eradicate rickets.
Further research into phosphate's role in bone health is warranted.