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Successful reduction of off-target hERG toxicity by structural modification of a T-type calcium channel blocker

Yeon Jae Choi1, Jae Hong Seo1, Kye Jung Shin1

  • 1Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon, Gyeonggi-do 420-743, Republic of Korea.

Bioorganic & Medicinal Chemistry Letters
|January 14, 2014
PubMed

Keywords:
L-type calcium channelPharmacokineticsT-type calcium channel blockerhERG

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