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Updated: May 4, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
Published on: November 11, 2018
RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions
Patrizia D'Adamo1, Michela Masetti2, Veronica Bianchi1
1Dulbecco Telethon Institute at San Raffaele Scientific Institute, Division of Neuroscience, via Olgettina 58, 20132 Milan, Italy; Vita-Salute San Raffaele University, via Olgettina 58, 20132 Milan, Italy.
Abstract:
A RAS-related class of small monomeric G proteins, the RAB GTPases, is emerging as of key biological importance in compartment specific directional control of vesicles formation, transport and fusion. Thanks to human genetic observation and to the consequent dedicated biochemical work, substantial progress has been made on the understanding of the role played by RAB GTPases and their effector proteins on neuronal development and the shaping of cognitive functions. This review is highlighting these initial elements to broaden the current scope of research on developmental cognitive deficits and take the point of view of RAB GTPases control on membrane transport in neurons and astrocytes.
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