A hypothetical model on the mechanism of anesthesia
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Medical Hypotheses
|May 1, 1987
Abstract:
An hypothesis on the mechanism of action of general anesthetic agents is proposed. It is based on a potentiation of chloride influx due to the action of anesthetic agents on the GABA-receptor complex at the lipid-protein interface. This hypothesis accommodates various observations such as lipid solubility of anesthetic molecules, their lack of stringent structural requirement, pressure reversal of anesthetic action, and other neurochemical and neuropharmacological data.