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Related Experiment Video

Updated: May 4, 2026

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Challenges and prospects for biomarker research: a current perspective from the developing world.

Shabarni Gupta1, Apoorva Venkatesh1, Sandipan Ray1

  • 1Wadhwani Research Center for Biosciences and Bioengineering, Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Biochimica Et Biophysica Acta
|January 14, 2014
PubMed
Summary

Biomarker discovery in low and middle-income nations (LMNs) faces challenges like diverse disease patterns and limited resources. Addressing these requires standardized procedures and data sharing for effective diagnostics.

Keywords:
BiomarkerBiorepositoryDeveloping worldDisease heterogeneityFundingIP issue

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Area of Science:

  • Biomarker research
  • Translational medicine
  • Global health

Background:

  • Communicable and non-communicable diseases cause most deaths in low and middle-income nations (LMNs), often due to delayed diagnosis and treatment.
  • Biomarkers are crucial for early disease detection and monitoring treatment response.
  • Research findings from developed nations may not apply to LMNs due to diverse disease patterns.

Purpose of the Study:

  • To review the challenges in biomarker discovery, validation, and translation in LMNs.
  • To highlight potential solutions and future prospects for biomarker research in these regions.

Main Methods:

  • Literature review focusing on biomarker research in LMNs.
  • Analysis of challenges including disease heterogeneity, pre-analytical variability, and socio-epidemiological factors.
  • Discussion of solutions such as standardized procedures and data repositories.

Main Results:

  • Biomarker candidate identification via omics technologies is promising but limited by heterogeneity and variability.
  • Economic, educational, and infrastructural limitations hinder biomarker discovery in LMNs.
  • Ethical and social issues further complicate biomarker research ventures.

Conclusions:

  • Standardized operating procedures and comprehensive data repositories are essential to reduce variability and fragmentation.
  • Addressing the unique challenges in LMNs is critical for advancing biomarker research and improving global health outcomes.
  • Collaboration and data sharing are key to overcoming hurdles in biomarker discovery and translation.