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Urinary bladder, cystitis and nerve/urothelial interactions.

Lori A Birder1

  • 1Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Autonomic Neuroscience : Basic & Clinical
|January 14, 2014
PubMed
Summary
This summary is machine-generated.

Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) causes pelvic pain without infection, impacting quality of life. Research explores its causes and effective treatments for this complex condition.

Keywords:
Autonomic nervous systemSensory functionTransducer functionUrothelium

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Area of Science:

  • Urology
  • Pain Medicine
  • Gastroenterology

Background:

  • Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC) is a functional pain syndrome characterized by suprapubic pain and urinary symptoms.
  • It affects primarily women, significantly impacting quality of life due to severe pain and urinary frequency.
  • The syndrome lacks clear definitions, proven etiologies, and universally effective treatments.

Purpose of the Study:

  • To summarize the current understanding of Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC).
  • To highlight the challenges in diagnosing and treating BPS/IC.
  • To discuss potential etiologies and co-morbidities associated with BPS/IC.

Main Methods:

  • Review of existing literature on Bladder Pain Syndrome/Interstitial Cystitis (BPS/IC).
  • Analysis of characteristic symptoms including suprapubic pain, urgency, frequency, and nocturia.
  • Exploration of proposed pathological mechanisms and co-occurring conditions.

Main Results:

  • BPS/IC presents with pain unrelated to infection or clear pathology.
  • Symptoms include suprapubic pain, urinary urgency, frequency, and nocturia.
  • Co-morbidities like irritable bowel syndrome and fibromyalgia are common.

Conclusions:

  • BPS/IC is a complex condition with significant quality of life implications.
  • Further research is needed to establish clear definitions, etiologies, and effective treatments.
  • Potential contributing factors include altered bladder lining and possible bacterial involvement.