Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

10.4K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a functional sarcopenia model utilizing a microcantilever microphysiological system as a phenotypic disease model.

In vitro models·2026
Same author

Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity.

bioRxiv : the preprint server for biology·2025
Same author

Translation of a Human-Based Malaria-on-a-Chip Phenotypic Disease Model for In Vivo Applications.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

LDL-Bound PCSK9 Has a Slower Clearance Kinetic and Higher Use for HSPGs Than Free-PCSK9-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology·2025
Same author

Bioengineered Human Cardiac Ventricular Model with Transmural Helical Remodeling.

Advanced healthcare materials·2025
Same author

Trans-epithelial/endothelial electrical resistance (TEER): Current state of integrated TEER measurements in organ-on-a-chip devices.

Current opinion in biomedical engineering·2025

Related Experiment Video

Updated: May 4, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

32.1K

How multi-organ microdevices can help foster drug development.

Mandy B Esch1, Alec S T Smith2, Jean-Matthieu Prot1

  • 1Department of Biomedical Engineering, Cornell University, 115 and 305 Weill Hall, Ithaca, NY 14853, USA.

Advanced Drug Delivery Reviews
|January 14, 2014
PubMed
Summary

Multi-organ microdevices simulate human metabolism and tissue interactions for drug development. These advanced systems improve prediction of drug efficacy and toxicity, moving beyond traditional animal models.

Keywords:
Body-on-a-chipMPSMicro-cell culture analogs of PBPKsMicrophysiological systemsMulti-organ microdevicesμCCAs

More Related Videos

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

7.3K
Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis
12:41

Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis

Published on: December 23, 2022

5.9K

Related Experiment Videos

Last Updated: May 4, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

32.1K
An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
08:59

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

Published on: December 3, 2020

7.3K
Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis
12:41

Multiparametric Tumor Organoid Drug Screening Using Widefield Live-Cell Imaging for Bulk and Single-Organoid Analysis

Published on: December 23, 2022

5.9K

Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Toxicology

Background:

  • Multi-organ microdevices replicate in vitro tissue-tissue interactions via metabolite exchange.
  • These systems model human metabolism, including pro-drug activation, therapeutic effects, and toxic side effects.

Purpose of the Study:

  • To review the development and application of multi-organ microdevices for studying drug action.
  • To highlight the potential of these devices in improving pharmaceutical development and enabling personalized medicine.

Main Methods:

  • Review of existing studies on multi-organ microdevice development and application.
  • Discussion of single-organ devices as precursors to multi-organ systems.

Main Results:

  • Multi-organ microdevices offer improved prediction of drug efficacy, dose response, and toxicity compared to animal models.
  • These devices provide a platform for testing drugs within a human metabolism context, aiding therapeutic strategy development.

Conclusions:

  • Multi-organ microdevices present unique opportunities for drug development, including personalized medicine applications.
  • Challenges in device design and authentic human metabolism mimicry require further research.