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Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Gap Junctions01:27

Gap Junctions

The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...

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Assaying Locomotor Activity to Study Circadian Rhythms and Sleep Parameters in Drosophila
18:08

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Published on: September 28, 2010

The Drosophila clock gene per affects intercellular junctional communication.

T A Bargiello, L Saez, M K Baylies

    Nature
    |August 20, 1987
    PubMed
    Summary

    The Drosophila per gene influences behavioral rhythms by altering salivary gland communication. Mutations in per affect gap junction channels, impacting intercellular signaling and potentially explaining rhythm disruptions.

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    Area of Science:

    • Neurobiology
    • Chronobiology
    • Cellular Biology

    Background:

    • The period (per) gene in Drosophila is crucial for regulating behavioral rhythms.
    • Per is notably expressed in salivary glands during embryonic and larval stages.
    • Per mutations significantly impact intercellular communication within these glands.

    Purpose of the Study:

    • To investigate the role of the per locus in Drosophila's behavioral rhythm control.
    • To understand how per mutations affect intercellular communication in salivary glands.
    • To explore the link between salivary gland communication and behavioral rhythmicity.

    Main Methods:

    • Analysis of per gene expression in Drosophila embryos and larvae.
    • Examination of salivary gland intercellular communication in wild-type and per mutant fruitflies.
    • Assessment of gap junction channel conductance in relation to behavioral rhythm periods.

    Main Results:

    • Per is expressed in Drosophila salivary glands.
    • Per mutations alter gap junction channel conductance in salivary glands.
    • The modulation of junctional communication is inversely correlated with the period of behavioral rhythms in mutants.

    Conclusions:

    • The per locus plays a significant role in modulating intercellular communication in Drosophila salivary glands.
    • Changes in gap junction conductance are linked to altered behavioral rhythm periods in per mutants.
    • Similar effects on nervous system junctional communication may underlie per's influence on behavioral rhythms.