Related Experiment Video
Updated: May 4, 2026
High-Throughput Capable Three-Dimensional Tissue Model for Quantification of Electroporation Thresholds
Published on: August 19, 2025
Irreversible electroporation: evolution of a laboratory technique in interventional oncology
Amy R Deipolyi1, Alexander Golberg, Martin L Yarmush
1From the Department of Imaging, Division of Interventional Radiology (A.R.D., R.S.A., R.O. e-mail: roklu@mgh.harvard.edu) and the Center for Engineering in Medicine (A.G., M.L.Y., R.O.), Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Abstract:
Electroporation involves applying electric field pulses to cells, leading to the alteration or destruction of cell membranes. Irreversible electroporation (IRE) creates permanent defects in cell membranes and induces cell death. By directly targeting IRE to tumors, percutaneous nonthermal ablation is possible. The history of IRE, evolution of concepts, theory, biological applications, and clinical data regarding its safety and efficacy are discussed.
